Mini-Workshop on Biological Systems and Applications
Organization : INCT-FCx, NAP-FCx
Chairman : Prof. Cristiano L. P. Oliveira
Venue : Adma Jafet Auditorium, Institute of Physics, University of São Paulo
Schedule
Thursday, August 27th
13:20 13:30 Welcome Cristiano L. P. Oliveira
13:30 14:30 Lipid nanoparticles as vehicles for the treatment of Atherosclerosis, Cancer and other degenerative diseases Raul Maranhão
14:30 15:30 Engineering several gates on octahedral DNA nanocages for a controlled trapping and release of useful payloads Alessandro Desideri
15:30 16:30 Receptor-mediated DNA nanocages entry into human cells: the case of LOX-1, a multiligand lipoprotein receptor Silvia Biocca
16:30 16:40 Closing Remarks Cristiano L. P. Oliveira
Speakers and Abstracts:
Prof. Raul Maranhão University of São Paulo
Lipid nanoparticles as vehicles for the treatment of Atherosclerosis, Cancer and other degenerative diseases
Prof. Silvia Biocca University of Rome Tor Vergata
Receptor-mediated DNA nanocages entry into human cells: the case of LOX-1, a multiligand lipoprotein receptor
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the primary receptor of ox-LDL in endothelial cells, is a multiligand lipoprotein receptor responsible for ox-LDL recognition, binding and internalization. It plays a central role in the pathogenesis of atherosclerosis and cardiovascular disorders. Here I will describe the molecular mechanism of LOX-1 binding to different ligands including LOX-1 inhibitors and DNA nanocages to be used in nanomedicine.
Prof. Alessandro Desideri University of Rome Tor Vergata
Engineering several gates on octahedral DNA nanocages for a controlled trapping and release of useful payloads
The recent development of biomedical nanotechnology is providing the appropriate know-how to build novel nanocarriers/nanocapsules to be used in the pharmaceutical industry for delivery of drugs and/or therapeutic payloads to specific cells. DNA is an extremely suitable polymer for the generation of nanocapsules being biocompatible, stable and chemically modifiable. Moreover, the simple four bases mechanism allows the auto-assembly of geometrically defined systems. In this presentation I will describe the general properties of DNA nanocarriers, how they can be functionalized for different tasks and how different opening/closing mechanisms can be engineered for a controlled release of useful payloads.
